Objectives: Quantication of BK virus (BKV) in urine and blood by PCR is a useful tool for detection of early stages of BKV reactivation and BKV-associated nephropathy in renal transplant patients. As the inter-laboratory molecular techniques are widely heterogeneous 12. BK virus Nephropathy BK viruria: 20 - 40 of renal transplant patients BK viremia: approx. 12 of patients Studies have indicated that BK viremia greater than 10e4/mL is predictive of definitive PVAN, and these patients should be regarded as having presumptive PVAN Neurological complications are not uncommon in patients with renal transplantation, mostly affecting the central nervous system, and less frequently the peripheral nerves. BK virus infection is relatively common in transplant recipients and in some cases may lead to neurological complications. Most renal transplant patients with BK virus nephritis manifest with or without renal dysfunction.Occasionally, patients may also report with ureteric obstruction, hydronephrosis and cystitis. Small case studies have demonstrated some efficacy of leflunomide to treat CMV disease in renal transplant patients.This occurs in 1 to 10 of patients with kidney transplantation and is caused by BK virus in more than 95 of cases. NKF 2011 Spring Clinical Meetings Abstracts 9 11 INCIDENCE OF BK VIRUS NEPHROPATHY IN HIV CRESCENTIC GLOMERULONEPHRITIS IN A PREDOMINATELY HISPANIC POSITIVE RENAL TRANSPLANT PATIENTS POPULATION IN THE US-MEXICO BORDER: A Are you sure your patient has renal transplant dysfunction? What are the typical findings for this disease? What other disease/condition shares some ofDharnidharka, VR, Abdulnour, HA, Araya, CE "The BK virus in renal transplant recipients-review of pathogenesis, diagnosis, and treatment". If the results of this study demonstrate the importance of the replication of BKV in renal transplant patients from the first month compared to that in immunocompetent subjects, the screening of theKeywords: BK Virus Renal Transplantation Urine and Plasma Viral Load Allograft Dysfunction. Named after the renal transplant patient (with initials B.K.) that it was rst isolated from in 1971, BK virus (BKV) is a Polyomavirus, characterised by its nonenveloped, icosahedral capsid and its circular, double-stranded DNA genome. 1983. Viral infection in the renal transplant patient. Proc. Eur.2006. Genetic variability in BK Virus regulatory regions in urine and kidney biopsies from renal-transplant patients. J. Med.
Virol. The BK virus was first isolated in 1971 from the urine of a renal transplant patient, initials B.K. The BK virus is similar to another virus called the JC virus (JCV), since their genomes share 75 sequence similarity. Infection with the human polyomaviruses JC virus and BK virus was studied in 61 immunosuppressed renal transplant patients. Urine cytologic studies, indirect immunofluorescence microscopy, electron microscopy, and serologic studies were used to assess viral activity. 12. BK virus Nephropathy BK viruria: 20 - 40 of renal transplant patients BK viremia: approx. 12 of patients Studies have indicated that BK viremia greater than 10e4/mL is predictive of definitive PVAN, and these patients should be regarded as having presumptive PVAN The aim of this study was to characterize BKV NCCR-variants in kidney biopsies and urine samples from renal-transplant patients and to see whether there is any association between NCCR variability and BKV-nephropathy.MeSH terms. BK Virus/genetics. With the introduction of new immunosuppressive agents, the outcome in renal transplant patients has significantly improved.
Due to emergence of opportunistic infection specifically BK virus, a number of transplant patients continue to have progressive graft dysfunction. u BK virus nephropathy (BKVN) has emerged as an important cause of renal graft dysfunction in recent decades. u It was first discovered in 1971 in a renal transplant patient named B.K. who developed ureteric stenosis after the viral infection. Renal transplant recipients with a high BK viral load exhibit elevated urine levels of IL-1 receptor antagonist protein, IL-3, IL-6 and IL-6 receptor compared with BKV-negative(2007) Prospective evaluation of BK virus DNAemia in renal transplant patients and their transplant outcome. The differentiation of BK virusassociated renal allograft nephropathy (BKVAN) from acute allograft rejection (AR) in renal transplant recipientsFigure 1. Surface-enhanced laser desorption/ionization (SELDI) analysis of urine samples from patients with BK virusassociated renal allograft BK Viremia After Renal Transplantation. Condition(s):Terminal Renal Failure BK Virus InfectionLast Updated:February 5, 2009Unknown status.Induction Related BK Viremia in Renal Transplant Patients. The human polyomaviruses, such as the BK and JC virus, are highly seroprevalent in humans but appear to cause clinical disease only in immunocompromised patients. BK virus is the primary cause of tubulointerstitial nephritis (BK virus nephropathy [BKVN]) and ureteral stenosis in renal transplant Detection of BK virus in urine from renal transplant subjects by mass spectrometry.Early monitoring of the human polyomavirus BK replication and sequencing analysis in a cohort of adult kidney transplant patients treated with basiliximab. Blzquez-Navarro A, Dang-Heine C, Or-Guil M, Bauer C, Westoff T, Hugo C, Reinke P, Sawitzki B, Babel N. BK Virus, Cytomegalovirus and Epstein-Barr VirusHow To Handle a Missed or Delayed Dose Intake? A Pharmacokinetic Study of Cyclosporine and Tacrolimus in Renal Transplant Patients. 7 Polyomavirus infection In renal transplant recipients, Polyomavirus-associated nephropathy (PVAN) develops in 5 of patients and leads to graft loss in approximately 50 of cases Pathogenesis of PVAN characterized by Persisting high-level polyoma BK virus (BKV) BK-virus nephropathy in renal transplants. the rst patients carrying the diagnosis of BKN in whom clinical experience was limited. Five of the eleven patients maintained graft function. Transplantation 2007. Donor origin of BK virus in renal transplant and role of HLA C7 in susceptibility to sustained viremia.Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Early detection of BKV infection in patients who have undergone a renal transplant is crucial to identify patients demanding closer clinical supervision.
BK virus nephropathy in renal transplant recipients. Nephrology (Carlton). 201621:64754.View ArticleGoogle Scholar. Contact the transplant clinic for more information. 1. Leca N, Muczynski KA, Jefferson JA, de Boer IH, Kowalewska J, Kendrick EA, et al. Higher levels of leflunomide are associated with hemolysis and are not superior to lower levels for BK virus clearance in renal transplant patients. BK viruria: 20 - 40 of renal transplant patients. BK viremia: approx.Recipient, donor, transplant, or viruses have been proposed as risk factors for PVAN after renal transplantation, including. Renal transplant patients have high risk for bladder cancer. The reactivation of BK virus is common in renal transplant patients especially in the urinary tract. There was some evidence suggesting that the reactivation of BK virus (BKV) in renal transplant patients may associate with the The BK virus was first isolated in 1971 from the urine of a renal transplant patient, initials B.K. The BK virus is similar to another virus called the JC virus (JCV), since their genomes share 75 sequence similarity. In the setting of immu-nosuppression BKV can reactivate and lead to BK virus nephropathy (BKVN) in renal transplant recipients.1It occurs with a prevalence of 110 in renal transplant patients and graft loss is up to 80.3,4 BKVN occurs mostly during the rst year after transplantation and it is Researchers find an association between late-onset BK virus nephropathy and less adherence to screening guidelines. Transient versus persistent BK viremia and long-term outcomes after kidney and kidney-pancreas transplantation. Higher levels of leflunomide are associated with hemolysis and are not superior to lower levels for BK virus clearance in renal transplant patients. Nephrol Dial Transplant 2003 18: 1190. 22. Lopez-Rocafort L, Wang C, Miller B. A prospective evaluation of BK virus infection in renal transplant patients [Abstract]. Am J Transplant 2002 2: S260. Human polyomavirus infection with JC virus and BK virus in renal transplant patients. Ann Intern Med 1980: 92: 373378.Diagnosis and management of BK polyomavirus interstitial nephri- tis in renal transplant recipients. Transplantation 1999: 68: 12791288. Abstract: Background: BK virus nephropathy (BKN) is recognized as a cause of graft loss in renal transplant patients. This may be related to the introduction of new and potent immunosuppressive regimens. Of the 25 patients, 10 were deceaseddonor transplant recipients and 15 were living-donor transplant recipients.Monitoring of BK virus replication in the first year following renal transplantation. Nephrol Dial Transplant. BK virus (BKV) has a high prevalence in the world population (> 80). Although it does not cause disease in immunocompetent patients, it remains latent in the kidneys and urinary tract1. Its reactivation in renal transplant recipients can lead to BKV-associated nephropathy (BKVAN). This is followed by BK viremia and BK virus nephropathy seen respectively in 5-30 and 1-10 of kidney transplant patients. BK virus nephropathy presents with renal dysfunction, which may be confused with acute rejection. Clinical course of polyoma virus nephropathy in 67 renal transplant patients. J Am Soc Nephrol. 200213(8):2145-2151.Donor origin of BK virus in renal transplantation and role of HLA C7 insusceptibility to sustained BK viremia. Am J Transplant. Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study.Keywords: polyomavirus, BK-virus, renal transplantation, anti-viral immunity, polyfunctionality. BK virus ne-phropathy in renal transplant patients in London. Transplantation 200885:1008-15. 4. Bohl DL, Brennan DC.Human polyomavirus infections with JC virus and BK vi-rus in renal transplant patients. Ann Intern Med 198092:373-8. BKV was first recognized in a renal-transplant patient diagnosed with the disease in 1971 as a result of virus reactivation due to new potent immunosuppressive medications aimed at reducing acute rejection and improving allograft survival.7 BKV-induced interstitial nephritis ( BK nephropathy) is not In this chapter, we describe some of the viral infections seen in the renal transplant population.In addition to unusual manifestations in BK virus nephritis, we have also seen the presence of viral co-infections common in these patients like CMV, chronic rejection, EBV and posttransplant Abstract/OtherAbstract: BACKGROUND: After renal transplantation, the prevalence of BK virus (BKV) viruria, viremia, and nephritis (BKVAN) has been estimated at 30BKV DNAemia was assessed systematically in 104 renal transplant patients on postoperative days 60, 90, 135, 180, 270, and 360. Background Although early monitoring of BK virus infection in renal transplant patients has led to improved outcomes over the past decade, it remains unclear whether monitoring for viremia is the best screening tool for BK virus nephropathy (BKVN). Key word: BK nephropathy, renal transplant, BK virus. Introduction: BKV, JC (John Cunningham) virus and Simian virus 40 belongs to polyomaviridae family. BK virus (BKV) infection is one of the most prevalent infections in kidney transplanted patients (1) BK virus-associated nephropathy in sirolimus-treated renal transplant patients: incidence, course, and clinical outcomes.Diagnosis and management of BK polyomavirus interstitial nephritis in renal transplant recipients. Transplantation 1999 68 (9): 1279. BK-virus-specific IgM antibody was detected in seven renal transplant recipients, six patients with malignant disease, and 13 healthy controls. In transplant recipients BK-virus-specific IgM antibody usually persisted throughout the duration of the study BK virus is a human polyoma virus that may cause nephropathy in immunosuppressed patients. It is a well-recognized cause of renal allograft dysfunction and allograft loss in renal transplant recipients, but it is an infrequent cause of nephropathy outside this setting.